Proton pump inhibitor–induced erythema dyschromicum perstans–like pigmentation
Abstract
Proton pump inhibitors (PPIs) are potent inhibitors of gastric acid secretion by parietal cells in gastric mucosa. Cutaneous pigmentation mimicking ashy dermatosis (AD)/erythema dyschromicum perstans (EDP) has been described with both omeprazole and esomeprazole. This report describes the presentation, histopathologic findings, and treatment of EDP-like pigmentation in the setting of lansoprazole and esomeprazole use.
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