Analysis on lansoprazole-induced microscopic colitis in 62 patients
Abstract
Objective
To analyze the clinical characteristics and risk factors of lansoprazole-induced microscopic colitis(MC).
Methods
PubMed, Da-Yi medical search, CHKD and Wanfang databases were searched and articles related to MC induced by lansoprazole were collected. The patients'primary diseases, coexisting diseases, the dosage, the way of administration, combination drugs, latent period, clinical manifestations, colonoscopic findings, the treatment measures, and the outcomes were recorded and the clinical characteristics, the risk factors of MC induced by lansoprazole were analyzed.
Results
A total of 30 articles and 62 patients with MCinduced by lansoprazole were retrieved. All articles were case reports and no randomized controlled trials were found. Of all the 62 patients, 22 were male (35.5%) and 40 were female (64.5%) with age from 36 to 92 years and the average age was (69±12) years; 57 patients (91.9%) were ＞50 years; 43 patients were with collagenous colitis(CC)(69.4%), 18 patients (29%) were with lymphocytic colitis(LC), and one patient with LC changed into CC(1.6%). All patients were treated with oral lansoprazole. The latent period of MCinduced by lansoprazole were 5d-6 years and within 1-6 months in 31 patients(60.8%). The most common clinical manifestations were non-bloody watery diarrhea (3-10 times daily in 59 patients,＞10 times daily in 3 patients). Intestinal mucosal screening was performed for all the patients and mild abnormalities or edema were observed in 37…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 62 participants or records.
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