Pharmacokinetic Study of Lansoprazole in Gastric Ulcer Patients and Healthy Volunteers
Abstract
OBJECTIVE:To compare the differences of pharmacokinetic profiles of lansoprazole between gastric ulcer patients and healthy volunteers in vivo.METHODS:12 male subjects (6 gastric ulcer patients and 6 healthy volunteers) were given Lansoprazole injection 250 mL via intravenous drip,and then the blood samples were collected at different time points.The concentration of lansoprazole was determined by HPLC-DAD.The pharmacokinetic parameters were analyzed using DAS2.0 software.RESULTS:The pharmacokinetic parameters of lansoprazole in healthy volunteers vs.gastric ulcer patients after intravenous administration were as follows:t1/2(2.369±1.51)h vs.(2.835±0.99)h,tmax(0.332±0.09) h vs.(0.277±0.05)h,CL(19.882±8.19)L·h-1 vs.(14.460±7.79) L·h-1,cmax(1 092.09±169.69) μg·L-1 vs.(910.76±69.91)ng·mL-1,AUC0～6.5(1 475.98±590.23)ng·h·mL-1 vs.(2 278.73±567.92)ng·h·mL-1,MRT0～6.5(1.633±0.44)h vs.(1.833±0.42)h.CONCLUSION:The pharmacokinetic profiles of lansoprazole in gastric ulcer patients have changed compared with healthy volunteers.
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