Short-Term Effect of Lansoprazole on Intragastric Acidity in Duodenal Ulcer Patients
Abstract
In the present study we evaluated the short-term effect of lansoprazole in controlling intragastric acidity in 20 patients with duodenal ulcer. Twenty- four hour intragastric acidity was measured respectively by ambulatory acidity monitors, before and after daily treatment of 30mg oral lansoprazole, for 1 and then 7 doses. The pretreatment of mean 24-hour median pH of 20 patients was 1.31 ± 0.28, then the mean 24-hour median pH was raised to 2.84±1.88 (P=0.002) after 1 dose. After 7 doses, the mean 24-hour median pH had raisen to 4.32±2.35 (P=0.018). 14 patients (70%) got a marked gastric acid, suppression. The acid suppression seemed not significantly correlated with basic characteristics (age, sex, height, weight) of these patients. In conclusion, our study demonstrates that short-term oral lansoprazole 30mg had major portion on intragastric acid suppression in patients with duodenal ulcer.
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