Effect of lansoprazole and exenatide on gastrin and oxyntomodulin in patients with type 2 diabetes
Abstract
Objective To observe glucose and lipids levels,body composition and insulin sensitivity before and after the treatment of exenatide and lansoprazole in type 2 diabetes mellitus( T2DM) patients,and to explore the effects of lansoprazole on the serum gastrin and oxyntomodulin( OXM). Methods Fifty-four obese patients with T2 DMwere randomly divided into combined treatment group( n = 27) and exenatide group( n = 27). Therapeutic plan of combined treatment group: 10 μg exenatide( subcutaneous injection one hour before breakfast and dinner) plus 15 mg lansoprazole were applied based on the original scheme; therapeutic plan of exenatide group: 10 μg exenatide( subcutaneous injection one hour before breakfast and dinner) was applied based on the original scheme. After 8 weeks of treatment,the changes in weight,body composition,blood pressure,fasting blood glucose( FBG),serum lipids,hepatic and renal functions,fasting insulin,glycosylated hemoglobin( Hb A1c),insulin resistance index( HOMA-IR),serum gastrin and OXMwere measured. Results Body weight,body composition,lowdensith lipoprotein( LDL),FBG,Hb A1 c,HOMA-IR and systolic pressure decreased significantly after treatment in both two groups( P 0. 05). Comapred withexenatide group,gastrointestinal discomfort was alleviated,serum gastrin level increased [( 160. 76 ± 8. 93) vs( 95. 30 ± 6. 01) ng /L,P 0. 05],FBG [( 8. 06 ± 2. 33) vs( 8. 51 ± 2. 71) mmol/L,P 0. 05]and Hb A1c[( 7. 79 ±0. 78) vs( 7. 87 ± 0. 81) %,P 0. 05] levels decresed…
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