Comparative Influence of Selected Antioxidants with Lansoprazole in Aspirin Induced Ulcer Model in Rats
Abstract
Gastric hyperacidity and ulcers are common gastrointestinal complications that affect a considerable number of people in the world. A number of excellent drugs, developed over the decades have proven useful in controlling hyperacidity and ulceration but still the problem of relapse has eluded success. Hence an attempt was made to find a therapy with more efficacy and better results. The present study was designed to evaluate the combination effect of selected antioxidants with lansoprazole against aspirin induced gastric ulcer model in rats. The experiment was conducted using 6 groups of albino rats with 6 animals each and the dose calculations were based on body surface area as described by Laurence and Bacharach. The antiulcer effect of the combination of antioxidants with lansoprazole was compared with the reference standard lansoprazole alone. The ulcer index and percentage protection was calculated. All the combination groups showed reduction in ulcer index and the percentage protection was found to be 92.1% for vitamin C + lansoprazole, 89.5% for coenzyme Q10 + lansoprazole, 90.8% for vitamin E + lansoprazole, 88.1% for melatonin + lansoprazole when compared to standard lansoprazole 82.8%. Thus all the combination groups of selected antioxidants with lansoprazole showed significant enhancement of antiulcer activity and were found to be synergistic in nature when compared to standard lansoprazole alone.
Read the paper
Related studies
- The Prediction of the In Vitro Release Curves for PLGA-Based Drug Delivery Systems with Neural Networks
- Promising Ursolic Acid as a Novel Antituberculosis Agent: Current Progress and Challenges
- Proof of principle concept for the analysis and functional prediction of rare genetic variants in the CYP2C19 and CYP2D6 genes
- Fabrication, characterization, and docking studies of furosemide-loaded nanosponges using the emulsion solvent diffusion method
- The Effect of Concomitant Administration of Proton Pump Inhibitors on the Pharmacokinetics of CDK4/6 Inhibitors in Rats: Implications for the Evaluation of Hepatic and Transporter-Mediated Drug–Drug Interactions
- Mining the Metabolic Capacity of Clostridium sporogenes Aided by Machine Learning
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.