Anti-Ulcer Activity of Lansoprazole in Experimental Ulcer Models
Abstract
Lansoprazole is considered a second-generation proton pump inhibitor, used for targetspecific acid suppression by inhibiting the parietal cell H+/K+-ATPase . But there is evidence that its clinical impact is not only from acid control , it also involves non-acid dependent cytoprotective mechanisms, kind of like additional safeguard routes. This systematic study tried to map that dual-action profile, by weighing its antisecretory strength against its own antioxidant and tissue remodeling effects across five well-validated rodent models of gastric injury. Adult Wistar rats were tested under five separate mucosal stressors: surgical pylorus ligation, absolute ethanol exposure, indomethacin dosing, water-immersion restraint stress , and serosal acetic acid application. In the pylorus ligation setup, 20 mg/kg Lansoprazole gave a significant (p < 0.01) protection rate of 84.37% , and it lowered gastric juice volume and total acidity , while raising pH. Then, in that acid-independent ethanol model, it curtailed the linear hemorrhagic necrosis down to smaller pinpoint petechiae, reaching 80.41% protection. It also kept strong mucosal defenses when prostaglandins were depleted (79.08% protection) and during neurogenic stress (81.07% protection). Plus, it sped up chronic ulcer healing overall, with 85.52% recovery. On the biochemical side, Lansoprazole reduced cell membrane lipid peroxidation , keeping malondialdehyde levels low. It also prevented depletion of endogenous antioxidant…
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