Antiulcerogenic activity of Cissampelos sympodialis Eichl. (Menispermaceae) in animal models
Abstract
Cissampelos sympodialis Eichl. (Menispermaceae) is an endemic species in Brazil, popularly known as "Milona", "Jarrinha" or "Orelha-de-onça". This species was selected for this study considering the chemotaxonomic (alkaloids and flavonoids) and ethnopharmacological criteria, due to this species be popularly used to treat inflammatory disorders. This study aimed to evaluate the acute preclinical toxicity and anti-ulcer activity of the ethanolic extract (EtOHE-Cs) and alkaloids total fraction (TAF-Cs) obtained from aerial parts of C. sympodialis. In acute toxicity, doses of 300 and 2000 mg/kg EtOHE-Cs were administered orally (p.o.). Our experiment conditions shows that, this type of doses did not induce signs of toxicity in female mice and 50% of lethal dose (LD50) is equal to or greater 5000 mg/kg according to the OECD 423 guide. For TAF-Cs was founded that the animals treated with the dose of 2000 mg/kg showed straub tail and analgesia. In addition, the LD50 of this substance being approximately 1000 mg/kg. To evaluate the gastroprotective activity using induced acute models of gastric ulcers were used: ethanol and containment of gastric juice in rats, anti-inflammatory non-steroidal drug (NSAID - piroxicam) and stress (immobilization and cold) in mice. In ulcer model induced by ethanol the results showed that carbenoxolone (100 mg/kg), EtOHE-Cs or TAF-Cs (62.5; 125; 250 and 500 mg/kg – v.o.) reduced the ulcerative lesion area (ULA) of 97, 69, 75, 94, 98; 97, 88, 90, 94,…
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