In vitro Evaluation of Gastro Retentive Drug Delivery System of Lansoprazole
Abstract
Objective: Drug given by orally is the simplest and easiest way in compared to other routes. But, the oral bioavailability of drugs is lower than other routes because it is influenced by first pass hepatic effect and absorption factors.To overcome therestrictions of conventional dosage forms like poor compliance, variability of drug leveland increase the bioavailability of the drugs for avoiding frequent dosing and subsequent degradation of drug in intestine, floating drug delivery system of lansoprazolewas explored in this study. Materials and Methods: By using floating tablets formulation, HPMC K4M and HPMC K15M were used as matrix forming agent. Microcrystalline cellulose, talc, sodium bicarbonate, citric acid and magnesium stearate (lubricating agent) are included in this formulations. The lack of any drug, polymers and excipients interactions were confirmedby Fourier transform infrared spectroscopy. Results: The results showed that F4 of HPMC K4M and F6 of HPMC K15M gave maximum release of drug upto 100% within 24hrs. All formulations were examined for five different models viz. zero and first order, Higuchi matrix, Peppas model and Hixson-Crowell equations and all the formulations according toPeppas model. Conclusion: This study showed that F4 of HPMC K4M series and F6 of HPMC K15M canbe stable for 30 days at 40oC and 75%relative humidity (RH) stability. It is suggested that a controlled release lansoprazole floating tablets may be developed from our study which will…
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