Formulation and development of statistical optimization of gastro-retentive drug delivery system: in-vivo and in-vitro study
Abstract
: This study focuses on the formulation and optimization of a gastro - retentive drug delivery system (GRDDS) for Lansoprazole and Clarithromycin, used in the treatment of Helicobacter pylori - associated peptic ulcers. The aim is to enhance gastric residence time and improve the local therapeutic effect through floating tablets. A design of experiment (DoE) approach, specifically Box - Behnken Design (BBD) or Central Composite Design (CCD), is used for statistical optimization. In - vitro buoyancy, drug release, and in - vivo gastric retention are evaluated to confirm the efficacy of the formulation.
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