Formulation and in-vitro Evaluation of orodispersible Tablets of Lansoprazole
Abstract
Lansoprazole a proton pump inhibitor used in the short term treatment of gastric and duodenal ulcer, reflux esophagitis, structuring and erosive esophagitis. The ulcer is an acute condition and requires an immediate treatment. An Orodispersible tablet disperses readily in saliva and the drug is available in solution or suspension form for the immediate absorption and resulting in rapid onset of action. In the present research work Lansoprazole orodispersible tablets were prepared by direct compression method using varying concentrations of Croscarmellose sodium, Sodium Starch Glycolate, Crospovidone as superdisintegrants. The formulations prepared were evaluated for various parameters like, hardness, weight variation, Friability, in vitro dispersion time, water absorption ratio, drug content uniformity and in vitro drug release. The tablets prepared were dispersed in the range of 8.3±0.6-23.7±1.5seconds, the water absorption ratio was 24.9±4.2-186.8±3.2% and the drug was uniformly dispersed in all the formulations in the range of 95.6±0.4-102.5±0.8%. Among the formulation prepared the tablet containing 7.5% of Crospovidone 99.736±0.763% of the drug within 18 min. The overall result indicated that the formulation F6 containing Crospovidone 7.5% is better and fulfilling of the needs of the orodispersible tablets
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