Effect of Surfactants on Lansoprazole Solid Dispersions: A Pathway to Improved Dissolution and Development of Fast Disintegrating Tablets
Abstract
Aim: The study aimed to enhance the solubility and dissolution rate of Lansoprazole, a poorly water-soluble drug, using binary and ternary solid dispersions (SDs) with polyethylene glycol (PEG) 6000 and surfactants such as Tween 80 and sodium dodecyl sulfate (SDS). Additionally, fast-disintegrating tablets (FDTs) were developed using optimized solid dispersions to improve drug release.
Methods: Binary and ternary solid dispersions of Lansoprazole were prepared using the solvent-melt method. Physical mixtures were also formulated for comparison. These formulations were characterized through aqueous solubility studies, Fourier-transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), and in vitro dissolution studies. The optimized solid dispersion was further incorporated into FDTs using different superdisintegrants. The FDTs were evaluated for pre-compression and post-compression parameters, including drug content, hardness, friability, disintegration time, and in vitro dissolution. Stability studies were conducted on the optimized formulation.
Results: The ternary solid dispersion (SSD3) containing PEG 6000 and SDS significantly improved the solubility of Lansoprazole (3.12 mg/mL) compared to the pure drug (0.022 mg/mL). XRD analysis indicated reduced crystallinity in the solid dispersions, contributing to enhanced dissolution rates. The in vitro dissolution study revealed that SSD3 achieved 88.70% drug release in 60 minutes. Among the FDT formulations, F10,…
Read the paper
Related studies
- The Prediction of the In Vitro Release Curves for PLGA-Based Drug Delivery Systems with Neural Networks
- Promising Ursolic Acid as a Novel Antituberculosis Agent: Current Progress and Challenges
- Proof of principle concept for the analysis and functional prediction of rare genetic variants in the CYP2C19 and CYP2D6 genes
- Fabrication, characterization, and docking studies of furosemide-loaded nanosponges using the emulsion solvent diffusion method
- The Effect of Concomitant Administration of Proton Pump Inhibitors on the Pharmacokinetics of CDK4/6 Inhibitors in Rats: Implications for the Evaluation of Hepatic and Transporter-Mediated Drug–Drug Interactions
- Mining the Metabolic Capacity of Clostridium sporogenes Aided by Machine Learning
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.