Study on the Correlation between Dissolution in Vitro and Absorption in Vivo of Lansoprazole Enteric-coated Tablets
Abstract
OBJECTIVE To investigate the dissolution rate in vivo and bioavailability in beagle dogs of lansoprazole enteric-coated tablets,and to evaluate the correlations of the dissolution in vitro and absorption in vivo.METHODS The drug dissolution in vitro was measured by UV spectrophotometer.The plasma concentration in beagle dogs was measured by HPLC.The correlation of dissolution in vitro and bioavailability in vivo was studied by the Wagnner-Nelson method.RESULTS The relationship between the dissolution fraction ft and the absorption fraction fa was fa=0.8122ft-9.874 6,r=0.956 8.CONCLUSION The correlation between dissolution in vitro and absorption in vivo of lansoprazole enteric-coated tablets was good.
Read the paper
Related studies
- The Prediction of the In Vitro Release Curves for PLGA-Based Drug Delivery Systems with Neural Networks
- Promising Ursolic Acid as a Novel Antituberculosis Agent: Current Progress and Challenges
- Proof of principle concept for the analysis and functional prediction of rare genetic variants in the CYP2C19 and CYP2D6 genes
- Fabrication, characterization, and docking studies of furosemide-loaded nanosponges using the emulsion solvent diffusion method
- The Effect of Concomitant Administration of Proton Pump Inhibitors on the Pharmacokinetics of CDK4/6 Inhibitors in Rats: Implications for the Evaluation of Hepatic and Transporter-Mediated Drug–Drug Interactions
- Mining the Metabolic Capacity of Clostridium sporogenes Aided by Machine Learning
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.