Formulation and in vitro evaluation of lansoprazole micropellets
Abstract
Pellets are agglomerates of fine powders or granules of bulk drugs and excipients. They consist of small, free flowing, spherical or semi-spherica l solid units, typically from about 0.5mm to 1.5mm, and are intended usually for oral administration. Pellets can be prepared by many methods, the compaction and drug-layering being the most widely used today 1 . The study was undertaken with an aim to develop delayed release micropellet dosage form for Lansoprazole which is a benzimidazole anti ulcer agent and is one of the most widely used drugs for treating mild and severe ulcers. The approach of the present study was to make a comparative evaluation among these polymers and excipients and to assess the effect of physicochemical nature of the active ingredients on the drug release profile. The prototype formulation of micro pellets were prepared using the fluid bed coater (FBC) with the air pressure 2.0 bar and the spray rate 10-15ml/min. Temperature of bed is varied from 35°C to 50°C and inlet temperature is varied from 50°C to 70°C and the effect of various parameter were observed such as air pressure, inlet and outlet temperature of FBC, it is observed that at high pressure the pellets are breaking. For bed and inlet temperature it is observed that at low temperature lumps are occurring in the formulation and at 2.0 bar air pressure, inlet temperature 60°C and bed temperature of 40°C is reliable for solution flow rate 10-15ml/min. Concerning results of prototype preparation…
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