Formulation and Evaluation of Floating In - Situ Raft System of Lansoprazole for Gastro - Retentive Drug Delivery
Abstract
Peptic ulcer disease and gastroesophageal reflux disease (GERD) are common gastrointestinal disorders associated with excessive gastric acid secretion. Lansoprazole, a proton pump inhibitor, is widely used in the treatment of these conditions; however, its conventional dosage forms exhibit limitations such as short gastric residence time and rapid drug elimination. The present study aimed to develop and evaluate a floating in - situ raft forming system of Lansoprazole to enhance gastric retention and provide sustained drug release. Floating raft formulations were prepared using sodium alginate as the primary gel - forming polymer and HPMC K4M as a viscosity enhancing agent. Calcium carbonate was used as a cross - linking agent, while sodium bicarbonate and citric acid served as gas - generating agents. A total of nine formulations (F1 – F9) were prepared using a 3² factorial design by varying polymer concentrations. The prepared formulations were evaluated for pH, viscosity, floating lag time, total floating time, and in - vitro drug release. All formulations showed acceptable pH and viscosity values suitable for oral administration. The floating lag time ranged from a few seconds to approximately two minutes, and all formulations demonstrated excellent buoyancy. In - vitro dissolution studies revealed sustained drug release for up to 12 hours. Among the formulations, F6 exhibited the highest drug release profile and optimum raft characteristics. The study concludes that the…
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