Formulation, Development and Evaluation ofOrodispersible Tablets of Lansoprazole
Abstract
The purpose of the present research work was to prepare & evaluate the ODT of Lansoprazole using Indion-414 & Indion-234 by Direct Compression method. Lansoprazole is a proton pump inhibitor (PPI) which is used in the management of acid-related disorders. Primarily powder blend (Drug & Excipients) was evaluated for precompression parameters and further tablet was compressed by direct compression method. Then the formulations were evaluated for weight variation, disintegration time, hardness, friability, drug content, water absorption ratio, wetting time, in vitro disintegration and in vitro dissolution. All the formulations showed low weight variation & from that F5 batch of Lansoprazole containing Indion- 234 (3% w/w) have less DT (12 sec), wetting time 18 sec % Drug release in 60 sec is 83% as compared to Indion-414 Dt Time was 17 sec. This work help in understanding the effect of formulation processing variables especially the resin which is used as a tablet disintegrant & the cost of resin is less as compared to conventional superdisintegrants. Also it gives rapid absorption, improved bioavailability, effective therapy and patient compliance.
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