Formulation and Evaluation of Press-Coated Tablets of Lansoprazole for Delayed Release Delivery
Abstract
Lansoprazole, a proton pump inhibitor, is widely used for the treatment of acid-related gastrointestinal disorders such as peptic ulcers and gastroesophageal reflux disease (GERD). However, lansoprazole is highly unstable in acidic environments and undergoes rapid degradation in gastric pH, which significantly reduces its bioavailability. Therefore, it requires protection through specialized drug delivery systems to ensure effective therapeutic action.The present study focuses on the formulation and evaluation of press-coated tablets of lansoprazole designed to achieve delayed release and protect the drug from gastric degradation. Core tablets containing lansoprazole were prepared and subsequently press-coated with polymeric layers using direct compression technique. Various formulations were developed using different polymers to optimize lag time and release characteristics.The prepared tablets were evaluated for pre-compression parameters such as angle of repose, bulk density, and compressibility index, and post-compression parameters including hardness, friability, weight variation, and drug content uniformity. In vitro dissolution studies were conducted using simulated gastric fluid (pH 1.2) followed by intestinal fluid (pH 6.8) to assess delayed release behavior.The optimized formulation demonstrated negligible drug release in acidic medium and significant drug release in intestinal pH after a defined lag time, confirming the effectiveness of press-coating technique.…
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