Formulation and Evaluation of Lansoprazole Nanosuspension: A Novel Pediatric Oral Drug-Delivery System
Abstract
Lansoprazole is a proton pump inhibitor widely used in the management of acid- related gastrointestinal disorders; however, its poor aqueous solubility presents a significant challenge during formulation development and may limit its dissolution performance. The present investigation was designed to develop and evaluate a nanosuspension-based oral formulation of lansoprazole to enhance its physicochemical characteristics and drug-release behavior. Five formulations (F1, F2, F3, F4, and F5) were prepared using Avicel as a polymer and Xanthan gum as a stabilizing agent using high shear homogenization. Preformulation analysis confirmed λmax at 285 nm with satisfactory linearity for quantitative estimation .Among the formulations, LNS-4 demonstrated the smallest droplet size (~178 nm) with low polydispersity, indicating uniform nanosuspension formation. Zeta potential values around −35 mV confirmed adequate electrostatic stability. All formulations were exhibited and were evaluated for various physicochemical parameters, including appearance, pH, sedimentation volume, redispersibility, density, surface tension, and in-vitro drug release. In-vitro release studies indicated a sustained drug release profile, with LNS-4 showing superior performance. UV spectrophotometric evaluation revealed strong absorbance within the UV range, supporting effective photoprotective activity. The prepared nanosuspensions were compared based on their overall evaluation results to identify the…
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