Studying the protective effect of Moringa Oleifera and lansoprazole contra indomethacin –induced gastric ulceration in male rats through prostaglandin modulation and restoration of histological changes
Abstract
Moringa oleifera is a medicinal plant widely recognized for its rich content of bioactive compounds such as flavonoids, phenolic compounds, alkaloids, tannins, saponins, vitamins, and antioxidants that contribute to its therapeutic potential against various pathological disorders, including gastric ulceration. The present study aimed to evaluate the therapeutic effects of Moringa oleifera extract and lansoprazole against indomethacin-induced gastric ulcers in rats. Ulcer-induced rats exhibited several clinical manifestations, including lethargy, anorexia, and melena, accompanied by a significant decrease (P < 0.05) in body weight to accomplish this, Forty adult Wistar rats were divided to 5 groups(n=8): control (C−) Administration of Distilled water (D.W) for 4weeks (orally) and other 4 groups induced gastric ulcer by administration with a single oral dose of indomethacin (30 mg/kg BW). Control positive (C+): (8 rat) Induced with acute gastric ulcer without any treatments. G1:(Moringa treatment): after 3 days of ulcer induction, administration with 200 mg/kg of Moringa leaf extract orally, for 4 weeks. G 2: (lansoprazole treatment): after 3 days of ulcer induction, administration with 20 mg/kg of lansoprazole orally for 4 weeks. G3: after 3 days of ulcer induction, administration with combination of MO (200mg/kg) and lansoprazole (20mg/kg) orally for 4 weeks. following ulcer induction. Treatment with Moringa oleifera extract significantly improved (P < 0.05) body weight and…
Read the paper
Related studies
- The Prediction of the In Vitro Release Curves for PLGA-Based Drug Delivery Systems with Neural Networks
- Promising Ursolic Acid as a Novel Antituberculosis Agent: Current Progress and Challenges
- Proof of principle concept for the analysis and functional prediction of rare genetic variants in the CYP2C19 and CYP2D6 genes
- Fabrication, characterization, and docking studies of furosemide-loaded nanosponges using the emulsion solvent diffusion method
- The Effect of Concomitant Administration of Proton Pump Inhibitors on the Pharmacokinetics of CDK4/6 Inhibitors in Rats: Implications for the Evaluation of Hepatic and Transporter-Mediated Drug–Drug Interactions
- Mining the Metabolic Capacity of Clostridium sporogenes Aided by Machine Learning
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.