Adjunctive Anweiyang capsules combined with Western medicine for peptic ulcer disease: a systematic review and meta-analysis of randomized controlled trials
Abstract
Introduction Anweiyang capsules, a Chinese patent medicine, are used to reinforce qi, resolve toxic substances, and promote healing. In this study, we aimed to conduct the first meta-analysis comprehensively evaluating the clinical effectiveness and safety of Anweiyang capsules combined with Western medicine for the treatment of peptic ulcer disease (PUD). Methods Eight databases were systematically searched up to July 2025 and the further updated to May 1, 2026. The Cochrane risk of bias (ROB) 2.0 tool was used to assess the risk of bias in the included randomized controlled trials (RCTs), and evidence quality was evaluated using the GRADE tool. Results Thirty-six RCTs involving 3858 patients were included. In subgroup meta-analyses based on the background Western medicine regimen, the addition of Anweiyang capsules was associated with a higher clinical effectiveness rate compared with Western medicine alone (standard quadruple therapy: risk ratio [RR] = 1.19, 95% confidence interval [CI]: 1.13, 1.24; standard triple therapy: RR = 1.11, 95% CI: 1.06, 1.16; other regimens: RR = 1.20, 95% CI: 1.16, 1.25). Similar associations were observed for Helicobacter pylori eradication (quadruple: RR = 1.24, 95% CI: 1.17, 1.31; triple: RR = 1.16, 95% CI: 1.10, 1.23; and other: RR = 1.20, 95% CI: 1.13, 1.27). Owing to heterogeneity, gastrointestinal hormones, cytokines, and angiogenic markers were analyzed descriptively, demonstrating reductions in gastrin, motilin, and interleukin-6,…
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Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 3,858 participants or records.
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