The Effect of Tarantula Cubensıs Alcoholic Extract on AOPP and Total Sulfhidryl Level in The Stomach Tissue of Gastric Damaged Rats with Indometazine
Abstract
There are many markers used to assess the oxidative stress state of the cell. Advanced oxidative protein products (AOPP), which are formed by the reaction of oxygen radicals with proteins in the cell, are one of these markers. Total sulfhydryl (t-SH) is accepted as an indicator of antioxidant status. Alcoholic extract of the spider Tarantula Cubensis (TCAE) is used as a homeopathic agent in the Veterinary medicine. TCAE has many therapeutic effects such as anti-inflammatory, antitumor, necrotizing action and wound healing. In this study, it was aimed to investigate the effect of TCAE on AOPP and t-SH levels in the stomach tissue of rats with indomethacin-induced gastric damage. For this purpose, the rats were divided into 4 groups (n=7) as control, Indomethacin (25 mg/kg indomethacin), Indomethacin + Lansoprazole (25 mg/kg indomethacin +30 mg/kg lansoprazole) and Indomethacin +TCAE (25 mg/kg indomethacin + 200 µg/kg TCAE) group. Five minutes after lansoprazole and TCAE administration, all rats except the control group were given a single dose of indomethacin (25 mg/kg) orally, and six hours after indomethacin administration, the gastric tissue was removed for biochemical analysis under anesthesia. Spectrophotometric method was used to measure AOPP and t-SH levels in gastric tissue. In the study, the effects of TCAE were compared with the effects of lansoprazole used in the treatment of ulcers. A statistically significant (p<0.05) increase was found in the AOPP and t-SH…
Read the paper
Related studies
- The Prediction of the In Vitro Release Curves for PLGA-Based Drug Delivery Systems with Neural Networks
- Promising Ursolic Acid as a Novel Antituberculosis Agent: Current Progress and Challenges
- Proof of principle concept for the analysis and functional prediction of rare genetic variants in the CYP2C19 and CYP2D6 genes
- Fabrication, characterization, and docking studies of furosemide-loaded nanosponges using the emulsion solvent diffusion method
- The Effect of Concomitant Administration of Proton Pump Inhibitors on the Pharmacokinetics of CDK4/6 Inhibitors in Rats: Implications for the Evaluation of Hepatic and Transporter-Mediated Drug–Drug Interactions
- Mining the Metabolic Capacity of Clostridium sporogenes Aided by Machine Learning
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.