Evaluation of In Vivo Anti Ulcer Potential of Ethanolic Extract of Tecoma stans Flower in Albino Rats
Abstract
Aims: To evaluate the anti-ulcer activity of ethanolic extract of Tecoma stans flowers in albino rats and preliminary phytochemical constituents.Study design: Experimental animal based in-vivo study.Methods: Flower extract of Tecoma stans was screened for phytochemical constituents.Anti-ulcer activity by determination of gastric mucus content ph by using adult albino rats and the animals were divided into 5 groups, Group I(normal control) -Normal saline, Group II(negative control) -Ethanol (96% 5ml/kg), Group III(standard treatment) -Ethanol (96% 5ml/kg)+ Lansoprazole (15mg/kg), Group IV(test group)-Ethanol(96% 5ml/kg)+Tecoma stans extract (200 mg/kg), Group V(test group)-Ethanol (96% 5ml/kg)+Tecoma stans extract (400 mg/kg) respectively.The treatments will be administered orally via gavage for a duration of 7 days, after which the rats will be euthanized, and the gastric mucosa will be examined for ulcer formation.Gastric mucus acid pH and histopathology of stomach were performed.Results:The preliminary phytochemical constitutents of the extract was identified as alkaloids, flavonoids, phenolic compounds, saponins and tannins indicating that the bioactive constituents.In the control group, indicating no ulceration or cellular damage.The ethanol-induced ulcer group showed significant mucosal erosion, cellular disruption, and inflammation.The group treated with Lansoprazole showed some improvement in the gastric mucosa.The group treated with 200 mg/kg of Tecoma Stans extract…
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