A New Model to Correlate Solubility of Therapeutic Drugs in Supercritical Carbon Dioxide
Abstract
In this work, a new solubility model was proposed based on the enhancement factor concept. The proposed model is validated with the literature available solubility data of seventeen therapeutic drugs in supercritical carbon dioxide. The correlating ability of the proposed model was compared with the Chrastil model and Bartle et al. model. The global average absolute relative deviation (AARD) percentages of Chrastil, Bartle et al. and new models were 19.42%, 19.57% and 16.43%, respectively. Sublimation enthalpies of therapeutic drugs were calculated with a new model as well as with Bartle et al. model. The calculated sublimation enthalpies ranged between 8.32 to 180.23 kJ/mol and 19.5 to 280.26 kJ/mol for the Bartle et al. model and the Improved Bartle model, respectively. Finally, a statistical analysis was performed in terms of Alaike's Information Criterion (AIC) to differentiate models considered in this work.
Read the paper
Related studies
- The Prediction of the In Vitro Release Curves for PLGA-Based Drug Delivery Systems with Neural Networks
- Promising Ursolic Acid as a Novel Antituberculosis Agent: Current Progress and Challenges
- Proof of principle concept for the analysis and functional prediction of rare genetic variants in the CYP2C19 and CYP2D6 genes
- Fabrication, characterization, and docking studies of furosemide-loaded nanosponges using the emulsion solvent diffusion method
- The Effect of Concomitant Administration of Proton Pump Inhibitors on the Pharmacokinetics of CDK4/6 Inhibitors in Rats: Implications for the Evaluation of Hepatic and Transporter-Mediated Drug–Drug Interactions
- Mining the Metabolic Capacity of Clostridium sporogenes Aided by Machine Learning
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.