Gastro-protective activities of misoprostol and omeprazole on aspirin-induced gastric ulceration in rat model
Abstract
Purpose: To evaluate the gastroprotective effects of misoprostol and omeprazole co-administration on aspirin-induced gastric ulceration in Wistar rats. Method: Gastric ulcers were induced in Wistar albino rats by oral administration of aspirin (200 mg/kg) once daily for six consecutive days. Animals were divided into five groups of five rats each: normal control, aspirin control, and three treatment groups receiving misoprostol (2 mg/kg), omeprazole (20 mg/kg), and a combination of both drugs, respectively, at the same doses. All treatments were given orally once daily, simultaneously for six days. Ulcer index, pH levels, antioxidant indices, and histological changes were assessed 24 hours after the last treatment, following sacrifice. Result: Aspirin administration significantly (p < 0.05) decreased pH and increased the ulcer index in rats. Treatment with misoprostol and omeprazole significantly (p < 0.05) improved acidity levels and inhibited ulceration, with combination therapy showing the best protection. Aspirin-induced ulceration is associated with increased lipid peroxidation and reduced superoxide dismutase and catalase activities. All treatments significantly (p < 0.05) improved the antioxidant parameters, with omeprazole alone exhibiting the most potent antioxidant activity. Histological examination revealed significant changes in the gastric histoarchitecture of the aspirin-treated rats, including vascular congestion, degenerated epithelial mucosa, and…
Read the paper
Related studies
- The Prediction of the In Vitro Release Curves for PLGA-Based Drug Delivery Systems with Neural Networks
- Promising Ursolic Acid as a Novel Antituberculosis Agent: Current Progress and Challenges
- Proof of principle concept for the analysis and functional prediction of rare genetic variants in the CYP2C19 and CYP2D6 genes
- Fabrication, characterization, and docking studies of furosemide-loaded nanosponges using the emulsion solvent diffusion method
- The Effect of Concomitant Administration of Proton Pump Inhibitors on the Pharmacokinetics of CDK4/6 Inhibitors in Rats: Implications for the Evaluation of Hepatic and Transporter-Mediated Drug–Drug Interactions
- Mining the Metabolic Capacity of Clostridium sporogenes Aided by Machine Learning
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.