Uzun Süreli Kullanılan İlaçların Antimikrobiyal Etkisinin ve Antimikrobiyal Ajanlar ile İn Vitro Etkileşiminin Araştırılması
Abstract
People with chronic diseases have to use medication regularly and for a long time. Antimicrobial agents may be used concominantly together with these drugs. This study aimed to investigate the antimicrobial effects and interactions of frequently used drugs in chronic conditions when combined with other antimicrobial agents. The selected drugs included atorvastatin and rosuvastatin (statins), metoprolol and propranolol (beta-blockers) and lansoprazole and esomeprazole (proton pump inhibitors). In our study, standard microorganisms and resistant isolates in the culture collection obtained from the department of microbiology were studied. The antimicrobial activity of the drugs was determined using the microdilution method, while their combined effects with antibiotics were assessed using the checkerboard method. Our study showed that combining certain medications with antibiotics significantly reduced the minimum inhibitory concentration (MIC) values (ampicillin MIC for Staphylococcus aureus, vancomycin MIC for Enterococcus faecalis, ciprofloxacin MIC for Escherichia coli, imipenem MIC for Klebsiella pneumoniae, meropenem MIC for Acinetobacter baumannii, gentamicin MIC for Pseudomonas aeruginosa). In the presence of atorvastatin and rosuvastatin, MIC values of antibiotics against resistant S.aureus, E.faecalis, A.baumannii and K.pneumoniae isolates decreased by 4-fold or more. For the same agents, in resistant P.aeruginosa isolates, gentamicin MIC values was reduced by 2-64…
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