Development and assessment of polymeric nanoparticle-based capsule composites for peptic ulcer treatment
Abstract
The study focused on the formulation and evaluation of polymeric nanoparticle capsule composites, using a combination of natural polymer chitosan and synthetic polymer methylcellulose, to improve drug delivery systems. These polymers were chosen for their biocompatibility and ability to enhance drug stability and release. Among various formulations tested, formulation F2 emerged as the most optimized, demonstrating excellent performance across key parameters. F2 displayed the smallest particle size (78.04 nm), which enhances cellular uptake and increases the surface area available for drug interaction. The formulation also showed the highest entrapment efficiency (97.93%) and excellent drug content (98.84%), ensuring a high payload and effective drug delivery. The strong zeta potential (53.4 mV) further confirmed the formulation’s stability, minimizing aggregation and enhancing dispersion in biological systems. In vitro drug release studies showed that F2 had a remarkable release rate of 98.45% over 6 hours, outperforming all other formulations. This rapid drug release is beneficial for medications requiring fast absorption or quick therapeutic effects. Additionally, when compared to traditional lansoprazole capsules, F2 showed superior drug release, suggesting potential for better therapeutic outcomes. Animal studies also supported F2’s efficacy, as it effectively treated stomach inflammation and ulcerative conditions, showing superior therapeutic performance compared to…
Read the paper
Related studies
- The Prediction of the In Vitro Release Curves for PLGA-Based Drug Delivery Systems with Neural Networks
- Promising Ursolic Acid as a Novel Antituberculosis Agent: Current Progress and Challenges
- Proof of principle concept for the analysis and functional prediction of rare genetic variants in the CYP2C19 and CYP2D6 genes
- Fabrication, characterization, and docking studies of furosemide-loaded nanosponges using the emulsion solvent diffusion method
- The Effect of Concomitant Administration of Proton Pump Inhibitors on the Pharmacokinetics of CDK4/6 Inhibitors in Rats: Implications for the Evaluation of Hepatic and Transporter-Mediated Drug–Drug Interactions
- Mining the Metabolic Capacity of Clostridium sporogenes Aided by Machine Learning
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.