Effect of artemesia annua on in-vitro dissolution of various brands of metformin tablets
Abstract
Background: Metformin is the world's most commonly used antidiabetic drug for type 2 diabetes and this is major because it protects against diabetes-related mortality. Concurrent administration of metformin with herbal medicines causes interaction, which may lead to undesirable pharmacokinetic and pharmacodynamic effects. Aim: This study aimed to determine the effect of the methanol extract of Artemisia annua on the in-vitro dissolution of various brands of metformin tablets. Method: Five brands of metformin (500 mg) tablets were randomly purchased from different Pharmacies within the Kaduna metropolis. The in-vitro dissolution of different metformin tablet brands with methanol extract of Artemisia annua was carried out according to the BP 2009, using the dissolution apparatus type II (paddle apparatus) at the rate of 100 rpm at 37 ± 0.5⁰C, using the medium 900ml of a 0.68% w/v solution of potassium dihydrogen orthophosphate and the pH was adjusted to 6.8 by the addition of 1M sodium hydroxide while rotating the basket at 100 revolutions per minute. Results: All the brands of metformin tablets complied with official specifications for hardness, friability, disintegration, and assay. Conclusion: Therefore, based on invitro dissolution studies, the brands might be substituted with the innovator product in clinical practice. The results revealed that Artemisia annua lowers metformin's dissolution profile and subsequently its bioavailability.
Read the paper
Related studies
- The Prediction of the In Vitro Release Curves for PLGA-Based Drug Delivery Systems with Neural Networks
- Promising Ursolic Acid as a Novel Antituberculosis Agent: Current Progress and Challenges
- Proof of principle concept for the analysis and functional prediction of rare genetic variants in the CYP2C19 and CYP2D6 genes
- Fabrication, characterization, and docking studies of furosemide-loaded nanosponges using the emulsion solvent diffusion method
- The Effect of Concomitant Administration of Proton Pump Inhibitors on the Pharmacokinetics of CDK4/6 Inhibitors in Rats: Implications for the Evaluation of Hepatic and Transporter-Mediated Drug–Drug Interactions
- Mining the Metabolic Capacity of Clostridium sporogenes Aided by Machine Learning
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.