Evaluation of in- vitro Antiulcer Activity and Phytochemical analysis in Alcea rosea (Hollyhock)
Abstract
Alcea rosea, a member of the Malvaceae family, generally recognized as Hollyhock, is widely grown in gardens and parks across Asia and Southern Europe. Several medicinal investigations have revealed that this plant has pain-reducing, antibacterial, and anti-inflammatory qualities. The present study, In-vitro Antiulcer Activity of Alcea rosea, incorporated H+, K+-ATPase and Acid neutralizing capacity (ANC). At a concentration of 250 mg, sample QAR displayed the highest ANC per gram (98.0 meq/g), surpassing the given standard antacid (97.2meq/g), and implying significant acid neutralizing capability. Although slightly less than QAR, sample ARET as well exhibited considerable activity (82.4meq/gat250mg). The acid neutralizing capacity (ANC) investigation demonstrated that both the herbal samples tested and standard antacids had considerable acid neutralizing features. Sample-QAR and ARET were examined for their capacity to suppress H+, K+-ATPase, using omeprazole as the reference standard. Sample-QAR and omeprazole displayed inhibition rates of 70.49% and 65.57%, respectively, at a concentration of 100µg/ml. In the meantime, Sample-ARET displayed a 42.62% inhibition rate, showing that it has a reasonable amount of activity.
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