Design and In Vitro Characterization of Ilaprazole Microspheres Prepared by Ionotropic Gelation to Increase Bioavailability
Abstract
Floating microspheres are a promising gastroretentive drug delivery system designed to prolong gastric residence time and improve the bioavailability of drugs with narrow absorption windows, poor intestinal stability, or local action in the stomach. These low-density multiparticulate systems remain buoyant on gastric fluids for extended periods, enabling sustained and controlled drug release. Floating microspheres are commonly prepared using techniques ionotropic gelation method. Ilaprazole-loaded microspheres were prepared by the ionotropic gelation technique using sodium alginate and Eudragit polymers to achieve controlled gastric retention and sustained drug release. The formulated microspheres exhibited satisfactory entrapment efficiency, particle size distribution, buoyancy, and prolonged release characteristics, demonstrating their potential as an effective gastroretentive drug delivery system. Their performance is evaluated based on particle size, buoyancy, drug entrapment efficiency, surface morphology, and in vitro drug release characteristics. Advantages include reduced dosing frequency, enhanced therapeutic efficacy, improved patient compliance, and minimized fluctuations in plasma drug concentrations. The findings suggest that ionotropically gelled Ilaprazole microspheres represent a promising oral drug delivery system capable of enhancing bioavailability, prolonging therapeutic action, and improving patient compliance. Therefore, the developed microsphere…
Read the paper
Related studies
- The Prediction of the In Vitro Release Curves for PLGA-Based Drug Delivery Systems with Neural Networks
- Promising Ursolic Acid as a Novel Antituberculosis Agent: Current Progress and Challenges
- Proof of principle concept for the analysis and functional prediction of rare genetic variants in the CYP2C19 and CYP2D6 genes
- Fabrication, characterization, and docking studies of furosemide-loaded nanosponges using the emulsion solvent diffusion method
- The Effect of Concomitant Administration of Proton Pump Inhibitors on the Pharmacokinetics of CDK4/6 Inhibitors in Rats: Implications for the Evaluation of Hepatic and Transporter-Mediated Drug–Drug Interactions
- Mining the Metabolic Capacity of Clostridium sporogenes Aided by Machine Learning
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.