Indomethacin-Loaded Nanosponges for Oral Delivery: Formulation Strategy, Optimization, and In-vitro Evaluation
Abstract
Chronic illnesses like arthritis cause pain and inflammation, requiring extended oral analgesic therapy. To reduce adverse reactions, active pharmaceutical ingredients are administered through sustained-release dosage forms. However, methods like matrix tablets, osmotic systems, and ion exchange resins have limitations. Nanotechnological approaches like nanosponges improve precision and accuracy in medication release manufacturing. Encapsulated formulations offer benefits like reduced side effects, varied dose options, non-irritating properties, and aesthetic appeal. Nanosponges are used in formulation to provide stability, improve bioavailability, alter taste, and target medication distribution systems. βcyclodextrin-based nanoparticles are used to achieve active pharmaceutical ingredients characteristics. Polymers like ethylcellulose are commonly used for sustained-release formulations. Nanosponges can be synthesized using techniques like solvent technique, cross-linking, ultrasound-assisted preparation, and emulsion solvent diffusion. Ultrasound-assisted method is efficient and cost-effective. The study aims to develop indomethacin-loaded nanoparticles for a sustained-release tablet, obstructing prostaglandin synthesis, a chemical responsible for inflammation and discomfort. Indomethacin, a class II medication, is suitable due to its low solubility and molecular weight. This study developed and evaluated sustained release preparations of indomethacin-incorporated…
Read the paper
Related studies
- The Prediction of the In Vitro Release Curves for PLGA-Based Drug Delivery Systems with Neural Networks
- Promising Ursolic Acid as a Novel Antituberculosis Agent: Current Progress and Challenges
- Proof of principle concept for the analysis and functional prediction of rare genetic variants in the CYP2C19 and CYP2D6 genes
- Fabrication, characterization, and docking studies of furosemide-loaded nanosponges using the emulsion solvent diffusion method
- The Effect of Concomitant Administration of Proton Pump Inhibitors on the Pharmacokinetics of CDK4/6 Inhibitors in Rats: Implications for the Evaluation of Hepatic and Transporter-Mediated Drug–Drug Interactions
- Mining the Metabolic Capacity of Clostridium sporogenes Aided by Machine Learning
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.