Identification of potential drug candidates to treat gastritis and associated oxidative stress based on some novel 2-aryl-1 H -naphtho[2,3- d ]imidazole: synthesis, in vitro and in silico analysis
Abstract
, showed significant antioxidant activity. Molecular docking studies of the selected synthesized compounds 3, 4, 9, and 11 were also performed to determine their binding interaction with the jack bean urease. Through docking studies, it was revealed that all the compounds that showed good inhibitory potential against urease fit well within the protein's binding pocket. Furthermore, ADME analysis was carried out to explore the drug-likeness properties of the compounds. The findings of the present work revealed that compounds 4 and 11 could be better options to treat gastritis and associated oxidative stress.
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