Impact of Perioperative Proton Pump Inhibitors on Renal Cancer Progression. A Retrospective Study
Abstract
BACKGROUND: ATPase, targeted by proton pump inhibitors (PPIs). We also examined how perioperative use of these drugs affects cancer progression post-surgery. METHODS: Using a publicly available database, we employed in silico analysis to investigate the association between the ATP4A gene and recurrence-free survival and overall survival. After receiving institutional review board approval from the University of Texas-MD Anderson Cancer Center (#2020-0380), we conducted a retrospective analysis to investigate the association between perioperative PPIs use and progression of nonmetastatic ccRCC. We performed a propensity score analysis and utilized inverse probability of treatment weighting to balance potential discrepancies between exposure groups. A Cox proportional hazards model, weighted by inverse probability of treatment weighting, was subsequently fitted for multivariable analysis. RESULTS: ATP4A gene expression analysis showed that high tumor levels were associated with a significant reduction in overall survival. The analysis included a total of 1775 patients with ccRCC. After propensity matching, the analysis revealed that the use of perioperative PPIs was not independently associated with a worse oncological prognosis following nephrectomies. CONCLUSION: Elevated ATP4A gene expression correlates with reduced survival, while perioperative PPI use shows no significant impact on survival outcomes.
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