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Development of an artificial intelligence model for optimizing periodontal therapy decision-making: a retrospective longitudinal cohort study

T. Rebeiz, Ghida Lawand, William Martin, Luiz Gonzaga, Marta-Revilla León, S. Khalaf, J. Megarbané

E -journal of dentistry, 2025

9 citations

Abstract

OBJECTIVES

This study aims to develop and validate an artificial intelligence (AI) - driven model to assist periodontal therapy decision-making and minimize tooth loss.

METHODS

A retrospective longitudinal cohort study was conducted using clinical and radiographic data from 3,347 teeth treated and followed up for at least 10 years. The parameters included in the machine learning training and testing processes included: probing pocket depth (PPD), bone loss (BL), systemic diseases, therapy type, and others. Various machine learning models were developed and evaluated for accuracy, precision, recall, F1-score, and Area Under the Receiver Operating Characteristic Curve (AUC-ROC).

RESULTS

The Random Forest model demonstrated superior performance and was selected as the final predictive model achieving an AUC score of 0.91 and an accuracy of 0.93. Significant associations were found between tooth loss and variables such as age, PPD, bone loss, and furcation involvement.

CONCLUSION

This AI-driven platform may provide a reliable tool for stratifying periodontal therapy decisions and predicting tooth loss risk, offering clinicians a supportive approach to personalize treatment plans. However, the study's retrospective design and reliance on traditional clinical metrics highlight the need for future prospective studies.

CLINICAL SIGNIFICANCE

This study introduces and validates a novel AI-driven predictive model for periodontal therapy, utilizing data from treatment cases. Unlike…

How strong is the evidence?

Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence.

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