Personalized In Vitro Fertilization Protocols in Premature Ovarian Insufficiency and Male-Factor Infertility: A Case Series
Abstract
Case series Patients: Female, 30-year-old • Female, 29-year-old • Female, 39-year-old • Female, 36-year-old Final Diagnosis: Premature ovarian insufficiency Symptoms: Amenorrhea Clinical Procedure: — Specialty: Obstetrics and Gynecology Objective: Unusual clinical course Background The current literature lacks extensive case-based evaluations of primary ovarian insufficiency (POI) in the context of severe male-factor infertility. This case series presents 4 patients with extremely low AMH levels and varied male infertility, aiming to illustrate clinical decision-making and treatment outcomes. Adjunct therapies such as growth hormone (GH), dehydroepiandrosterone (DHEA), Sildenafil, and Pentoxifylline were incorporated to assess protocol effectiveness. Case Reports All 4 patients had low AMH levels and male partners with differing degrees of oligoasthenoteratozoospermia (OAT), except 1 with normozoospermia. Intracytoplasmic sperm injection (ICSI) was performed in all cases. The treatment protocols varied: 3 used high-dose gonadotropins (FSH 300-375 IU with LH and GH), while 1 used a minimal stimulation protocol (Clomiphene Citrate + FSH 150 IU). Embryo transfer methods included both fresh and frozen (FET). Two cycles failed to implant, 1 led to a biochemical pregnancy (β-hCG 9.22 mIU/mL), and 1 progressed to clinical pregnancy (25%), following endometrial receptivity enhancement in the normozoospermic case. Protocol adjustments were made based on ovarian response and sperm…
How strong is the evidence?
Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- Improving the translation of search strategies using the Polyglot Search Translator: a randomized controlled trial
- Nutritional, Physical, Cognitive, and Combination Interventions and Frailty Reversal Among Older Adults: A Randomized Controlled Trial
- Clinical characteristics and risk factors associated with COVID-19 severity in patients with haematological malignancies in Italy: a retrospective, multicentre, cohort study
- A randomized, controlled trial of oral propranolol in infantile hemangioma
- Clinical phenotypes of delirium during critical illness and severity of subsequent long-term cognitive impairment: a prospective cohort study
- Increased physical activity improves sleep and mood outcomes in inactive people with insomnia: a randomized controlled trial
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.