Retrieval-Augmented Generation (RAG) in Healthcare: A Comprehensive Review
Abstract
Retrieval-Augmented Generation (RAG) enhances large language models (LLMs) by integrating external knowledge retrieval to improve factual consistency and reduce hallucinations. Despite growing interest, its use in healthcare remains fragmented. This paper presents a Systematic Literature Review (SLR) following PRISMA guidelines, synthesizing 30 peer-reviewed studies on RAG in clinical domains, focusing on three of its most prevalent and promising applications in diagnostic support, electronic health record (EHR) summarization, and medical question answering. We synthesize the existing architectural variants (naïve, advanced, and modular) and examine their deployment across these applications. Persistent challenges are identified, including retrieval noise (irrelevant or low-quality retrieved information), domain shift (performance degradation when models are applied to data distributions different from their training set), generation latency, and limited explainability. Evaluation strategies are compared using both standard metrics and clinical-specific metrics, FactScore, RadGraph-F1, and MED-F1, which are particularly critical for ensuring factual accuracy, medical validity, and clinical relevance. This synthesis offers a domain-focused perspective to guide researchers, healthcare providers, and policymakers in developing reliable, interpretable, and clinically aligned AI systems, laying the groundwork for future innovation in RAG-based healthcare solutions.
Read the paper
Related studies
- Knowledge Management Perspective of Generative Artificial Intelligence
- Navigating Generative Artificial Intelligence Promises and Perils for Knowledge and Creative Work
- Characterizing the evolving research on enterprise content management
- Large language models and multimodal foundation models for precision oncology
- From Generative AI to Extended Reality: Multidisciplinary Perspectives on the Challenges, Opportunities, and Future of Educational Computing
- Generative Artificial Intelligence: A New Engine for Advancing Environmental Science and Engineering
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.