Personal hair dye use and the risk of bladder cancer: a case–control study from The Netherlands
Abstract
BackgroundSeveral studies have suggested an increased risk of bladder cancer among hairdressers, who are occupationally exposed to hair dyes. There has also been concern about a possible increased risk of bladder cancer among users of hair dyes. However, the association between personal hair dye use and bladder cancer risk remains inconclusive.ObjectiveIn this study, we examined associations between personal use of permanent and temporary hair dyes and bladder cancer risk in a population-based case–control study involving 1,385 cases (n = 246 women) and 4,754 controls (n = 2,587 women).MethodsParticipants filled out a questionnaire with regard to history of personal hair dye use and risk factors for bladder cancer. Unconditional logistic regression was used to calculate odds ratios (OR) and 95 % confidence intervals (CI), adjusted for age, smoking status, duration of smoking and intensity of smoking.ResultsAnalyses were restricted to women as less than 5 % of all men in the study ever used hair dyes. About 50 % of the women ever used hair dyes. Use of temporary hair dyes (OR, 0.77; 95 % CI, 0.58–1.02) or use of permanent hair dyes (OR, 0.87; 95 % CI, 0.65–1.18) was not associated with bladder cancer risk. No clear association between hair dyes and bladder cancer risk was found when dye use was defined by type, duration or frequency of use, dye color, or extent of use. Also, results were similar for aggressive- and non-aggressive bladder cancer. Age, educational level, and…
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