Association of FCGR2A rs1801274 and FCGR3A rs396991 polymorphisms with various autoimmune diseases: a meta-analysis
Abstract
Objectives: The aim of this systematic review with meta-analysis was to examine the association between the polymorphisms rs1801274 (FCGR2A H131R) and rs396991 (FCGR3A F158V) and susceptibility to autoimmune diseases (ADs), with a focus on the progress and novelty of studies published over the last two decades.
Methods: A meta-analysis systematically evaluated FCGR2A/3A gene variants in autoimmune diseases (ADs) using four genetic models: dominant, recessive, overdominant, and allelic contrast.
Results: The FCGR3A F158V polymorphism was significantly associated with immune thrombocytopenia in all four genetic models tested (dominant: OR = 2.67, 95% CI 1.94-3.67, for FV + VV vs. FF, recessive: OR = 2.38, 95% CI 1.78-3.19, for VV vs. FF + FV, overdominant: OR = 1.58, 95% CI 1.15-2.17, for FV vs. FF+VV, and allele comparison: OR = 1.97, 95% CI 1.70-2.29, for V vs. F, in the overall analyses). Statistically significant associations were also found between rheumatoid arthritis and FCGR3A F158V polymorphisms (recessive: OR = 1.36, 95% CI 1.09-1.69, for VV vs. FF + FV, and allele comparison: OR = 1.15, 95% CI 1.03-1.29, for V vs. F, in the overall analyses). Conversely, the overall analysis identified a negative association between the FCGR2A H131R polymorphism and rheumatoid arthritis in two genetic models (dominant: OR 0.83, 95% CI 0.69-1.00, for HR + RR vs. HH; allelic comparison: OR 0.86, 95% CI 0.76-0.97, for R vs. H).
Conclusion: This meta-analysis revealed an association…
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