Ciprofol Versus Propofol for Sedation in Gastrointestinal Endoscopy: A Systematic Review and Meta-Analysis in a Chinese Population
Abstract
Purpose: Ciprofol (HSK3486) is a novel intravenous anesthetic structurally similar to propofol; however, its advantages over propofol remain unclear. This study aimed to compare the safety, efficacy, and satisfaction outcomes of ciprofol and propofol during gastrointestinal endoscopy.
Patients and methods: This systematic review incorporated all available comparative trials assessing ciprofol versus propofol for endoscopic sedation following a comprehensive search strategy across eight biomedical databases-Web of Science, Embase, PubMed, and Cochrane Library, along with major Chinese repositories (CNKI, Wanfang, CBM, and VIP)-through September 2023. Evidence synthesis was conducted per PRISMA guidelines, with methodological rigor enhanced through prospective trial registry screening and implementation of GRADE framework for evidence grading.
Results: This systematic review included 45 randomized controlled trials involving 6884 patients who met predefined methodological and clinical eligibility thresholds. Very low to moderate certainty evidence showed that ciprofol induced sedation or anesthesia comparable to that of propofol (relative risk [RR]: 1.00, 95% confidence interval [CI]: 1.00 to 1.01), with both agents demonstrating similar procedural efficiency. Furthermore, ciprofol was associated with a reduced incidence of complications, including hypotension (RR: 0.60, 95% CI: 0.51 to 0.70), bradycardia (RR: 0.69, 95% CI: 0.56 to 0.85), nausea and vomiting (RR: 0.67, 95% CI:…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 6,884 participants or records.
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