Continuation versus discontinuation of intravenous oxytocin in the active phase of labour
Abstract
RATIONALE
Intravenous oxytocin is widely used to induce labour or to augment labour (i.e. enhance contractions to promote progression), with approximately one-quarter of pregnant women at term receiving the medication. While continuous administration of intravenous oxytocin stimulation from induction until birth is recommended by most clinical guidelines, this may increase the risk of uterine hyperstimulation, foetal distress, and adverse maternal and neonatal outcomes. Discontinuation of oxytocin in the active phase of labour could reduce these risks without compromising labour progression. However, evidence from randomised trials is conflicting, and optimal management is unclear.
OBJECTIVES
To assess the effects of the discontinuation of intravenous oxytocin stimulation in pregnant women during the active phase of induced or augmented labour.
SEARCH METHODS
We searched the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, Embase, Scopus, and Web of Science Core Collection, as well as ClinicalTrials.gov and the WHO International Clinical Trials Registry Platform. We also screened reference lists of included studies and relevant reviews, and contacted trial authors for additional data. No language or date restrictions were applied. The last search was conducted on 17 November 2025.
ELIGIBILITY CRITERIA
We included randomised controlled trials comparing continuation versus discontinuation (or placebo) of intravenous oxytocin in the active phase of labour (≥ 4…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 4,814 participants or records.
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