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Applications of artificial intelligence in endodontic education: a systematic review

Mustafa M, Almokhatieb AA, Abdulwahed A, Almufleh LS, Albader S, Bilal M

Frontiers in dental medicine, 2026

Abstract

Background: The growing bases of Artificial Intelligence (AI) applications ranging from diagnostic support to immersive training have rapidly advanced in the dental education field. Endodontics, by its very nature of relying so highly on a proper diagnosis and careful technical execution, is an indication through which AI may be best poised to succeed the most in specialty care.

Objective: The aim of this systematic review was to assess the role of artificial intelligence (AI): machine learning (ML), deep learning (DL), virtual/augmented reality (VR/AR) and large language models (LLMs) related to endodontic education based on available evidence published until September 2025.

Methods: This review was performed in accordance with the PRISMA 2020 guidelines. Publication databases were reviewed included PubMed, Scopus, Web of Science and Cochrane. Inclusion Criteria: Studies that evaluated any form of AI for didactic, preclinical or clinical education in endodontics and/or patient-centered education were included. Study characteristics, AI domains, applications and outcomes were extracted. Risk of bias and methodological quality were evaluated according to study design using RoB 2, ROBINS-I, AXIS, and AMSTAR-2 tools.

Results: Fifteen studies were included. Radiographic interpretation augmented by AI improved sensitivity and specificity to reduce false positive reporting especially for junior clinicians. In preclinical training, VR/AR simulations have shown to improve…

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