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Toward Trustworthy Chatbots: A Protocol for Red Teaming for Health Related Conversations

Hussain SA, Jackson DI, Lewis A, Fosler-Lussier E, Sezgin E

medRxiv : the preprint server for health sciences, 2025

Abstract

INTRODUCTION: Health-related chatbots are increasingly used to mediate conversations that carry clinical significance and emotional weight. Retrieval-augmented generation (RAG) can reduce factual errors ("hallucinations"), but the risks remain, with additional challenges coming from chatbots acting against behavioral safety and scope rules. Red teaming, an adversarial testing process that deliberately probes systems for failures before deployment, offers a way to surface potential risks. We describe a task-informed red-teaming protocol for health-related and patient-facing chatbots..

METHODS: Our protocol is composed of an error stratification, single and multi-turn attack evaluation, and a framework for mitigation techniques. We define an error framework that distinguishes Knowledge Adherence (KA: staying faithful to retrieved documents) from Behavioral Adherence (BA: following safety, tone, and scope instructions). Our single-turn attacks consist of seven attack vectors reflecting real-world pressures, including advice-seeking, user distress, and prompt injection. A subset of these vectors are evaluated in multi-turn attacks. We evaluate two mitigation strategies: (1) prompt augmentation, which adds explicit guardrails to the chatbot prompt, and (2) document augmentation, which adds a localized FAQ document to the retrieval corpus. Finally, we apply this protocol to a social care chatbot (specifically supporting Health-Related Social Needs (HRSN)), developed as an agentic…

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