Translation of Genomics Research at the Bedside: the promise and the challenge
Abstract
Much has already been written about the global perspective systems-scale studies have brought to the biomedical research field. It is this high vantage point that Kodama et al have chosen to identify candidate genes that may be involved in the pathogenesis of type 1 diabetes (T1D). The publication of this work gives us the opportunity to ponder the pathways leading to the translation of genomics research into therapies and diagnostics that will benefit patient at the bedside.
Indeed, we have not yet found a clear path for the translation of genomics research into medical advances. The field of genomics has been fueled by remarkable technological accomplishments, with the first widely publicized step being the sequencing of the human genome, followed next by the introduction of gene expression microarrays and more recently single nucleotide polymorphism (SNP) genotyping chips. These technologies have now reached a level of maturity sufficient to produce high quality data at low cost. In fact, the next technological revolution is already upon us with the recent introduction of high-throughput sequencers that will permit to accomplish all of the above better, faster and, now that the race for the $1000 genome is in on, eventually at a much lower cost. Although it is hard resisting the impulse of associating this new wave of technological breakthrough to commensurate medical advances we should know by now that it might not necessarily happen, or at least not immediately. Indeed,…
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