Ceftazidime-avibactam activity against urinary carbapenem resistance Escherichia coli and Klebsiella pneumoniae isolates
Abstract
Background and Objectives: Urinary tract infections (UTIs) are among the most prevalent bacterial infections in women, with Escherichia coli and Klebsiella pneumoniae as leading causative pathogens. The emergence of multidrug-resistant (MDR) and carbapenem-resistant strains poses a significant therapeutic challenge. Ceftazidime–avibactam (CZA) has shown activity against β-lactamase-producing Gram-negative bacteria; however, data on its activity against urinary carbapenem-re- sistant isolates remain limited. This study aimed to determine CZA activity against urinary carbapenem-resistant E. coli and K. pneumoniae isolates.
Materials and Methods: In this cross-sectional study, antimicrobial susceptibility testing was performed using the disk dif- fusion method according to CLSI guidelines. The tested antibiotics included carbapenems, third-generation cephalosporins, aminoglycosides, levofloxacin, fosfomycin, and CZA. Extended-spectrum β-lactamase (ESBL) production was assessed using the combined-disk method.
Results: A total of 76 previously collected urinary bacterial isolates, including 44 (57.9%) E. coli and 32 (42.1%) K. pneumo- niae isolates were included in this study. Carbapenem resistance was detected in 25.0% (11/44) of E. coli and 28.1% (9/32) of K. pneumoniae isolates. ESBL production was observed in 36.4% and 37.5%, respectively. Overall, CZA susceptibility was 68.2% for E. coli and 68.7% for K. pneumoniae, decreasing to 27.3% and 22.2%, respectively, among…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause.
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