Microbacterium resistens Peritoneal Dialysis-Associated Peritonitis: A Case Report
Abstract
Peritoneal dialysis (PD)-associated peritonitis is most commonly caused by Gram-positive organisms; however, infections due to unusual pathogens can present important diagnostic and management challenges. Microbacterium resistens is an environmental Gram-positive bacillus rarely implicated in human infections, and PD-associated peritonitis due to this organism has been reported only once previously, to our knowledge. We report a case of persistent PD-associated peritonitis caused by M resistens in a 65-year-old man receiving automated PD combined with once-weekly hemodialysis. The initial episode was treated by prioritizing the already identified Enterococcus casseliflavus; an initially unidentified Gram-positive bacillus was subsequently identified as M resistens. The patient experienced multiple subsequent episodes despite sequential systemic and intraperitoneal antimicrobial therapies. Although effluent leukocyte counts repeatedly normalized with treatment, M resistens was repeatedly isolated with unchanged antimicrobial susceptibility profiles, suggesting persistent catheter colonization rather than acquired antimicrobial resistance. A definitive cure was achieved only after PD catheter removal. This case highlights that apparent clinical response with effluent leukocyte normalization does not necessarily indicate microbiological eradication in rare device-associated infections and that early catheter removal should be considered when the same unusual organism is…
How strong is the evidence?
Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- Ferulic acid regulates the AKT/GSK-3β/CRMP-2 signaling pathway in a middle cerebral artery occlusion animal model
- Novel Pharmacokinetic/Pharmacodynamic Parameters Quantify the Exposure–Effect Relationship of Levofloxacin against Fluoroquinolone-Resistant Escherichia coli
- Photochemical behavior of levofloxacin
- Correlation Between Dissolution Profiles of Salt-Form Drugs in Biorelevant Bicarbonate Buffer and Oral Drug Absorption: Importance of Dose/ Fluid Volume Ratio
- Evaluation of the synergistic potential and mechanisms of action for de novo designed cationic antimicrobial peptides
- Synthesis of [11C]levofloxacin
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.