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A Multimodal AI Framework for Medical Education: Integrating Adaptive Image Retrieval, Fast Synthesis, and LLM-Based Clinical Auditing

Díaz-Benito M, Diana-Albelda C, García-Martín Á, Paz Campos MR, Bescos J

Journal of imaging, 2026

Abstract

Access to reliable medical images is essential for clinical training. To address this need, this paper presents an extended version of MIRAGE, a multimodal retrieval and generation system that utilizes a shared latent space to process medical queries by retrieving real images from the ROCO dataset, generating synthetic scans, and providing LLM-based clinical descriptions alongside dual-concept visual comparisons. To overcome previous computational limits and the lack of clinical validation, we introduce three core enhancements: first, an Auto-α module to dynamically weight visual and textual similarities; second, the integration of LCM-LoRA to accelerate synthetic image generation; and third, an automated clinical auditor based on Gemini 2.5 Flash. Experimental results demonstrate that Auto-α improves retrieval accuracy for heterogeneous queries, reaching 38.83% Top-1 Recall over a 65,419-image gallery and outperforming nine fusion baselines evaluated under a unified configuration, with a controlled ablation attributing most of this gain to learning the weight rather than merely making it query-adaptive, while the LCM-LoRA module reduces computational costs by a factor of 12.5× in CPU environments, with a blinded radiologist evaluation confirming only a small drop in clinical quality. Furthermore, the clinical auditor achieves a 0.805 Pearson correlation against an expert radiologist, effectively correcting the systematic overestimation of traditional CLIP scores. Finally,…

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