Evidence-based guideline: premature ovarian insufficiency†‡
Abstract
Abstract Study question How should premature/primary ovarian insufficiency (POI) be diagnosed and managed, based on the best available evidence from published literature? Summary answer The current guideline provides 145 recommendations on symptoms, diagnosis, causation, sequelae and treatment of POI. What is known already POI presents a significant challenge to women’s health, with far-reaching implications, both physically and emotionally. The potential implications include adverse effects on quality of life, on fertility and on bone, cardiovascular and cognitive health. Although hormone therapy (HT) can mitigate some of these effects, many questions still remain regarding the optimal management of POI. Study design, size, duration The guideline was developed according to the structured methodology for development of European Society of Human Reproduction and Embryology (ESHRE) guidelines. Key questions were determined by a group of experts and informed by a scoping survey of women and healthcare professionals. Literature searches and assessment were then performed. Papers published up to 30 January 2024 and written in English were included in the guideline. An integrity review was conducted for the randomized controlled trials on POI included in the guideline. Participants/materials, setting, methods Based on the collected evidence, recommendations were formulated and discussed within the guideline development group until consensus was reached. Women with lived experience…
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