Deep Learning for CT Synthesis in Radiotherapy
Abstract
With the rapid development of artificial intelligence (AI), various deep learning (DL) methods have been introduced into radiation oncology. Among them, the generation of synthetic Computed Tomography (sCT) images has attracted increasing attention, as it supports different clinical scenarios, from image-guided adaptive radiotherapy (IGART) to the simulation-free workflow. This review provides a comprehensive overview of recent studies on DL-based sCT synthesis in radiotherapy from multiple imaging modalities, including Cone-Beam CT (CBCT), Magnetic Resonance Imaging (MRI), and diagnostic CT, and discusses their clinical applications in CBCT-based online adaptive radiotherapy, MRI-guided radiotherapy, and simulation-free workflows. We also examine the architectures of representative DL models such as convolutional neural networks (CNNs) and generative adversarial networks (GANs) and summarize emerging training strategies. Finally, we discuss current challenges of clinical translation of DL algorithms into clinical practice and suggest potential directions for future research. Overall, this paper highlights the potential of AI-driven sCT generation to advance treatment planning by reducing imaging burden, improving dose accuracy, and accelerating workflow efficiency, thus ultimately improving the treatment outcome of patient care.
Read the paper
Related studies
- Learning from First-Generation Qualitative Approaches in the IS Discipline: An Evolutionary View and Some Implications for Authors and Evaluators (PART 1/2)
- Commentary on the clinical and preclinical dosage limits of interstitially administered magnetic fluids for therapeutic hyperthermia based on current practice and efficacy models
- Prosthesis: New Technological Opportunities and Innovative Biomedical Devices
- The history and future of neural modeling for cochlear implants
- Ryanodine receptors: waking up from refractoriness
- Novel Transgenic Rabbit Model Sheds Light on the Puzzling Role of Matrix Metalloproteinase-12 in Atherosclerosis
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.