MRI for diagnosing uterine sarcoma: a systematic review and meta-analysis
Abstract
PURPOSE: To systematically review and meta-analyze the diagnostic accuracy of magnetic resonance imaging in differentiating uterine sarcomas from benign leiomyomas, thereby providing updated evidence for the revision of the Japan Radiological Society Diagnostic Imaging Guidelines. EVIDENCE ACQUISITION: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses of Diagnostic Test Accuracy Studies guidelines, a comprehensive literature search was performed by an independent information specialist to identify studies published between July 2019 and April 2025. Inclusion criteria required studies evaluating MRI (the combination of T2-weighted imaging and at least one additional sequence (diffusion-weighted imaging and/or contrast-enhanced imaging)) in patients with myometrial masses suspicious for sarcoma, with diagnostic performance assessable by 2 × 2 contingency tables. The reference standard was histopathology for malignant lesions, whereas benign diagnoses could be established by histopathology or by clinical/imaging follow-up. Data extraction and Quality Assessment of Diagnostic Accuracy Studies-2 quality assessment were performed independently. Pooled sensitivity and specificity were estimated using a random-effects model, and the hierarchical summary receiver operating characteristic (HSROC) curve was generated to estimate the area under the curve (AUC). EVIDENCE SYNTHESIS: Twelve studies met the inclusion criteria. All were retrospective, and…
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