Review of Physiology, Pathology, and Pharmacology of Voltage-Gated Sodium Channels in Regards to the Potential Role of NaV 1.8 Selective Agonist, Suzetrigine, for Chronic Pain Management
Abstract
Christopher M Lam,1 Christopher L Robinson,2 Rohit Aiyer,3 Robin Mata,4 Kristal Xie,5 Matthew Slitzky,6 Huma Latif,7 Edward B Braun,1 Michael E Schatman,8,9 Christopher Gilligan,10 Amol Soin,11,12 Usman Latif1 1Department of Anesthesiology and Interventional Pain Medicine, the University of Kansas Health System, Kansas City, KS, USA; 2Division of Pain, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA; 3Westside Pain Management, Long Beach, CA, USA; 4Department of Anesthesiology and Pain Medicine, Rush University Medical Center, Chicago, IL, USA; 5John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA; 6Burke Rehabilitation, Montefiore Health System, White Plains, NY, USA; 7School of Pharmacy, University of Missouri-Kansas City, Kansas City, KS, USA; 8Department of Anesthesiology, Perioperative Care and Pain Medicine, NYU Grossman School of Medicine, New York, NY, USA; 9Department of Population Health - Division of Medical Ethics, NYU Grossman School of Medicine, New York, NY, USA; 10Department of Anesthesiology and Perioperative Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA; 11Department of Surgery, Wright State University, Dayton, OH, USA; 12The Ohio Pain Clinic, Dayton, OH, USACorrespondence: Christopher M Lam, Email [email protected]: Voltage-gated sodium channels are integral for various physiologic processes including neurological signaling and…
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