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Deep learning in neurosurgery: a systematic literature review with a structured analysis of applications across subspecialties

Yangi K, Hong J, Gholami AS, On TJ, Reed AG, Puppalla P, Chen J, Calderon Valero CE et al.

Frontiers in neurology, 2025

79 participants · 18 citations

Abstract

Objective: This study systematically reviewed deep learning (DL) applications in neurosurgical practice to provide a comprehensive understanding of DL in neurosurgery. The review process included a systematic overview of recent developments in DL technologies, an examination of the existing literature on their applications in neurosurgery, and insights into the future of neurosurgery. The study also summarized the most widely used DL algorithms, their specific applications in neurosurgical practice, their limitations, and future directions.

Materials and methods: An advanced search using medical subject heading terms was conducted in Medline (via PubMed), Scopus, and Embase databases restricted to articles published in English. Two independent neurosurgically experienced reviewers screened selected articles.

Results: A total of 456 articles were initially retrieved. After screening, 162 were found eligible and included in the study. Reference lists of all 162 articles were checked, and 19 additional articles were found eligible and included in the study. The 181 included articles were divided into 6 categories according to the subspecialties: general neurosurgery (n = 64), neuro-oncology (n = 49), functional neurosurgery (n = 32), vascular neurosurgery (n = 17), neurotrauma (n = 9), and spine and peripheral nerve (n = 10). The leading procedures in which DL algorithms were most commonly used were deep brain stimulation and subthalamic and thalamic nuclei localization (n =…

How strong is the evidence?

Evidence Hub reads this as a systematic review. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 79 participants or records.

How the five levels of evidence work. The level is assigned automatically from the abstract and can be wrong, so check the paper.

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